... A web-based Atlas of Patient-Derived Xenografts of cancer patients:A resource of MURAL PDX data
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PDX model details

PDX ID 275R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 18
Average PDX Generation Time (days +/- SEM) 99 ± 9
Tumor preparation Tumor solid
Tumor Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumor confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 275R
AR Y
PSA Y
PSMA Y
NE N
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
275R CHD7 0.87599 3.67053 gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
275R CHD7 0.548925 2.92599 gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
275R MYC 0.525896 2.87966 gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
275R RB1 -0.931422 1.04868 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
275R TP53 -1.02398 0.983516 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
275R TP53 -0.792427 1.15474 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19

Clinical Information

Sample Number 275R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumor Diagnosis Adenocarcinoma
Gleason Score 7
Primary Gleason Score 4
Secondary Gleason Score 3
Tertiary Gleason Score None
ISUP Grade Group 3
Tumor Grade pT3bN0
D'Amico Risk Classification 8
Tumor Volume (in cc) 3.2
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 275
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 45
Consent to share data

Patient Tumor Collection (Current Model)
Tumour sample ID 275R
Patient Age (binned in 5 year age groups) 65-69
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
275R TH 145 0.54 missense_variant '4/14 7.90E-05 21.3 Uncertain_significance Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
275R AKT1 1657 0.49 missense_variant '10/13 . 29 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
275R MITF 559 0.48 missense_variant '9/10 1.63E-05 31 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
275R BRCA1 988 0.47 missense_variant '10/24 0.0002358 12.77 Benign Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
275R ZNF717 33 0.36 stop_lost '5/5 . 0.964 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
275R ZNF717 33 0.36 stop_lost '5/5 . 0.964 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
275R ZNF717 60 0.32 stop_gained '5/5 . 23.7 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
275R ZNF717 60 0.32 stop_gained '5/5 . 23.7 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500