PDX model details
PDX ID
162R
Host Strain(and Source)
NSG Source: Monash University
Host Strain Immune system Humanized
NO
Host Type
Testosterone supplemented
Graft Site
Renal
Current Generation (* indicates number of generations grown in Castrate host)
13
Average PDX Generation Time (days +/- SEM)
205 ± 8
Tumor preparation
Tumor solid
Tumor Characterization Technology
Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumor confirmed not to be of Mouse/EBV origin
Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed
Routine QA every 2-3 passages
Associated meta data
PDX model availability
Yes (fixed, frozen)
Governance restriction for distribution
Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID
34413304
Markers
162R
AR
Y
PSA
Y
PSMA
Y
NE
Y
ERG
N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.
This table displays curated CNVs
PDX ID
Gene Symbol
CNV Log2
CNV Copy
CNV Call
Experiments name
Platform
Reference genome
162R
NCOR2
0.564571
2.9579
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
KMT2C
-0.909919
1.06443
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
FANCA
-1.14347
0.905339
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
ZFHX3
-0.9207
1.05651
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
CDH1
-1.17596
0.885178
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
MGA
-1.10871
0.927417
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
RB1
-0.97255
1.01921
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
USP28
-0.989575
1.00725
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
ATM
-0.989575
1.00725
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
KMT2C
0.946605
3.85466
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
USP7
0.516235
2.86044
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
AKT3
0.652363
3.14348
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
STAB2
0.600703
3.03291
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
MRE11A
0.602488
3.03667
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
CCND1
1.74449
6.70153
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
MYC
0.957382
3.88357
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
SETDB1
0.494023
2.81673
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
KMT2C
1.03929
4.11043
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
EZH2
1.03929
4.11043
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
BRAF
1.03929
4.11043
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
162R
MET
1.03929
4.11043
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
Clinical Information
Sample Number
162R
Sample Site
Prostate
Sample source
Radical prostatectomy
Pathology Tumor Diagnosis
Adenocarcinoma
Gleason Score
8
Primary Gleason Score
4
Secondary Gleason Score
4
Tertiary Gleason Score
None
ISUP Grade Group
4
Tumor Grade
pT3aN0
D'Amico Risk Classification
7
Tumor Volume (in cc)
3.4
Treatment Prior to Specimen Collection
None
Patient Information
Patient Number
162
Sex
Male
Diagnosis
Prostate Cancer
PSA at diagnosis (ng/mL)
5.8
Consent to share data
This heatmap displays the mutations of curated sequence variants.
Download
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
PDX ID
Gene Symbol
Depth
ALT_FREQ
Consequence
Exon
GnomAD_AF
CADD_PHRED
Clinvar_clnsig
Platform
Experiments Name
Reference
Library Type
Instrument Type
162R
SETBP1
392
0.48
missense_variant
'4/6
.
26.7
-
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
162R
XIRP2
524
0.45
missense_variant
'9/11
6.52E-05
28.1
-
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
162R
NCOR2
522
0.32
frameshift_variant
'34/47
.
.
-
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
162R
FOXA1
396
0.31
inframe_deletion
'2/2
.
.
-
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
No information in Drug dosing Table