PDX model details
PDX ID
224R
Host Strain(and Source)
NSG Source: Monash University
Host Strain Immune system Humanized
NO
Host Type
Testosterone supplemented
Graft Site
Subcutaneous
Current Generation (* indicates number of generations grown in Castrate host)
27
Average PDX Generation Time (days +/- SEM)
75 ± 7
Tumor preparation
Tumor solid
Tumor Characterization Technology
Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumor confirmed not to be of Mouse/EBV origin
Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed
Routine QA every 2-3 passages
Associated meta data
PDX model availability
Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution
Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID
34413304
Markers
224R
AR
Y
PSA
Y
PSMA
Y
NE
Y
ERG
N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.
This table displays curated CNVs
PDX ID
Gene Symbol
CNV Log2
CNV Copy
CNV Call
Experiments name
Platform
Reference genome
224R
CHD1
0.834706
3.56699
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
TCERG1
0.734349
3.32729
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
GEMIN5
0.734349
3.32729
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
CHD7
0.654146
3.14737
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
MRE11A
0.528785
2.88543
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
ATM
0.528785
2.88543
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
USP7
0.51106
2.85019
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
PALB2
0.51106
2.85019
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
U2AF1
0.691395
3.22969
gain
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
SMARCAD1
-1.40139
0.757128
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
MGA
-1.40331
0.756122
loss
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
224R
PTEN
-20.9924
0.000000959
homdel
MURAL Prostate Cancer PDX collection
Targeted Twist Panel
hg19
Clinical Information
Sample Number
224R
Sample Site
Prostate
Sample source
Radical prostatectomy
Pathology Tumor Diagnosis
Mixed Adeno & Neuro
Gleason Score
9
Primary Gleason Score
4
Secondary Gleason Score
5
Tertiary Gleason Score
None
ISUP Grade Group
5
Tumor Grade
pT3b
D'Amico Risk Classification
7
Tumor Volume (in cc)
8.0
Treatment Prior to Specimen Collection
None
Patient Information
Patient Number
224
Sex
Male
Diagnosis
Prostate Cancer
PSA at diagnosis (ng/mL)
5.1
Consent to share data
This heatmap displays the mutations of curated sequence variants.
Download
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
PDX ID
Gene Symbol
Depth
ALT_FREQ
Consequence
Exon
GnomAD_AF
CADD_PHRED
Clinvar_clnsig
Platform
Experiments Name
Reference
Library Type
Instrument Type
224R
TP53
328
1.0
missense_variant
'8/11
.
21.1
Likely_pathogenic
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
224R
DOT1L
453
0.52
missense_variant
'26/28
4.06E-06
29.1
-
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
224R
TP63
471
0.46
missense_variant,splice_region_variant
'11/14
7.32E-05
16.64
-
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
224R
HOXB13
376
0.34
missense_variant
'2/2
.
27.4
-
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
224R
SOX9
236
0.27
missense_variant
'3/3
.
23.6
-
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
224R
FAM46C
390
0.27
missense_variant
'2/2
1.63E-05
24.4
-
Targeted Twist Panel
MURAL Prostate Cancer PDX collection
hg19
paired
NextSeq 500
No information in Drug dosing Table