... A web-based Atlas of Patient-Derived Xenografts of cancer patients:A resource of MURAL PDX data
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PDX model details

PDX ID 224R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 27
Average PDX Generation Time (days +/- SEM) 75 ± 7
Tumor preparation Tumor solid
Tumor Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumor confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 224R
AR Y
PSA Y
PSMA Y
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
224R CHD1 0.834706 3.56699 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R TCERG1 0.734349 3.32729 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R GEMIN5 0.734349 3.32729 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R CHD7 0.654146 3.14737 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R MRE11A 0.528785 2.88543 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R ATM 0.528785 2.88543 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R USP7 0.51106 2.85019 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R PALB2 0.51106 2.85019 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R U2AF1 0.691395 3.22969 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R SMARCAD1 -1.40139 0.757128 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R MGA -1.40331 0.756122 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R PTEN -20.9924 0.000000959 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 224R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumor Diagnosis Mixed Adeno & Neuro
Gleason Score 9
Primary Gleason Score 4
Secondary Gleason Score 5
Tertiary Gleason Score None
ISUP Grade Group 5
Tumor Grade pT3b
D'Amico Risk Classification 7
Tumor Volume (in cc) 8.0
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 224
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 5.1
Consent to share data

Patient Tumor Collection (Current Model)
Tumour sample ID 224R
Patient Age (binned in 5 year age groups) 60-64
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
224R TP53 328 1.0 missense_variant '8/11 . 21.1 Likely_pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R DOT1L 453 0.52 missense_variant '26/28 4.06E-06 29.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R TP63 471 0.46 missense_variant,splice_region_variant '11/14 7.32E-05 16.64 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R HOXB13 376 0.34 missense_variant '2/2 . 27.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R SOX9 236 0.27 missense_variant '3/3 . 23.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R FAM46C 390 0.27 missense_variant '2/2 1.63E-05 24.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500