... A web-based Atlas of Patient-Derived Xenografts of cancer patients:A resource of MURAL PDX data
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PDX model details

PDX ID 201.1A Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 61 (30*)
Average PDX Generation Time (days +/- SEM) 39 ± 2
Tumor preparation Tumor solid
Tumor Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumor confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304; 30049486
Markers 201.1A Cx
AR Y
PSA Y
PSMA Y
NE N
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
201.1A Cx CUL3 -1.02474 0.982998 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx USP28 -0.901016 1.07102 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx CDKN1B -1.06926 0.953127 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx TP53 -0.937453 1.04431 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx ERF -0.907982 1.06586 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx CDKN2A -0.996957 1.00211 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx RB1 -28.0281 0.00000000731 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx PTEN -16.8186 0.0000173 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 201.1A
Sample Site Dura
Sample source Autopsy
Pathology Tumor Diagnosis Adenocarcinoma
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumor Grade
D'Amico Risk Classification
Tumor Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, abiraterone, enzalutamide

Patient Information

Patient Number 201
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumor Collection (Current Model)
Tumour sample ID 201.1A
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
201.1A Cx ZMYM3 198 1.0 stop_gained '2/25 . 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AR 280 1.0 missense_variant '4/8 . 23.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AR 236 0.99 missense_variant '8/8 . 25.3 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MLH1 70 0.93 inframe_insertion,splice_region_variant '10/19 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MLH1 84 0.79 splice_acceptor_variant . . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx STAT4 249 0.55 splice_acceptor_variant . . 28.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx TGFBR2 162 0.54 frameshift_variant '4/8 0.0003621 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ERBB4 228 0.54 splice_donor_variant . . 34 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MUTYH 499 0.54 missense_variant '13/16 0.0007924 20.7 Conflicting_interpretations_of_pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ARFRP1 348 0.53 missense_variant '7/7 . 29.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx LRP2 584 0.53 missense_variant '25/79 . 25.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MYH14 395 0.51 frameshift_variant '25/43 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AXIN2 273 0.51 frameshift_variant '7/11 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx CACNA1H 438 0.5 missense_variant '9/35 8.90E-05 5.716 Uncertain_significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx SPTA1 321 0.5 missense_variant,splice_region_variant '4/52 . 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx TCERG1 330 0.49 frameshift_variant '20/22 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MYH14 425 0.49 splice_acceptor_variant . . 26.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx GSK3B 287 0.49 missense_variant '6/12 . 27.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx GLI2 387 0.49 missense_variant '14/14 . 24.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx GLI2 343 0.48 missense_variant '4/14 4.06E-06 29.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MSH2 304 0.48 missense_variant '16/16 6.12E-05 27.7 Uncertain_significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx KMT2D 457 0.47 missense_variant '48/54 . 33 Conflicting_interpretations_of_pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx OGDH 563 0.47 frameshift_variant '22/23 . 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx KMT2C 398 0.47 stop_gained '36/59 0 40 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx SIX3 289 0.47 frameshift_variant '1/2 0 28.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ARID4A 314 0.47 frameshift_variant '16/24 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx BBC3 534 0.47 frameshift_variant '4/4 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MYH14 443 0.46 missense_variant '30/43 . 28 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx XIRP2 338 0.46 frameshift_variant '9/11 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ZFHX3 496 0.46 frameshift_variant '2/10 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx TOP2A 415 0.46 frameshift_variant '34/35 3.31E-05 . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ATR 218 0.46 frameshift_variant '20/47 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx PPP2R1A 507 0.46 missense_variant '4/15 . 27.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx SIRT1 209 0.45 frameshift_variant '1/9 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx NCAM1 239 0.45 frameshift_variant '1/19 . 24.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx NCOR2 583 0.45 frameshift_variant '29/47 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AIP 467 0.45 missense_variant '6/6 . 29.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MGA 339 0.44 splice_donor_variant . . 25.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AXIN2 481 0.44 frameshift_variant '8/11 0 . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx BLM 281 0.43 frameshift_variant '7/22 2.95E-05 . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx CTNNB1 448 0.43 missense_variant '3/15 . 29.9 Pathogenic/Likely_pathogenic,_other Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx TERT 479 0.42 missense_variant '2/16 . 5.144 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx BRCA2 286 0.42 frameshift_variant '11/28 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx CHEK2 367 0.42 splice_donor_variant . . 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx FANCE 474 0.41 frameshift_variant '4/10 8.53E-05 22.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MSH6 374 0.41 frameshift_variant '4/10 . 24.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx PARP10 398 0.39 missense_variant,splice_region_variant '10/11 . 24.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx NFE2L1 329 0.39 frameshift_variant '2/6 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx KMT2C 322 0.34 frameshift_variant '38/59 4.07E-05 24 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ASXL1 559 0.33 frameshift_variant '13/13 0.0004861 34 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx GRM7 456 0.27 frameshift_variant '3/10 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500

PDX ID Treatment1 Dose (mg/kg) Frequency Treatment2 Dose (mg/kg) Frequency Response
201.1A Cx Carboplatin 50 qwk NA NA NA No response
201.1A Cx Talazoparib 0.33 qd Carboplatin 50 qwk No response
201.1A Cx Talazoparib 0.33 qd NA NA NA No response